Autoimmune Disease Is Rising in Young People

Autoimmune disease isn’t just affecting older adults — it’s increasingly impacting teens, college students, and young professionals. In fact, a major NIH-supported analysis found that markers of autoimmunity in U.S. adolescents have tripled over recent decades. This means more young people are showing early immune system changes that increase the likelihood of developing an autoimmune disease.

This pattern is consistent worldwide. Global studies show a steady rise in autoimmune diagnoses among adolescents and young adults from 1990 through the 2020s, reflecting broader changes in the environment, infection patterns, stress, and immune vulnerabilities. While researchers are still exploring why this is happening, one thing is clear: today’s young adults are being diagnosed at higher rates than ever before.

The environment also affects how people manage their disease. For instance, extreme weather like heatwaves or storms can cause power outages. This is a problem for people who need to keep their medicine cold, like certain shots or insulin. Poor air quality can make it harder to breathe and increase tiredness in people with autoimmune conditions. As these problems happen more often, it becomes harder to keep symptoms under control.

Scientists are studying this link between the environment and autoimmune diseases more closely, hoping to find better ways to prevent and treat these illnesses. It’s important for patients to learn how their surroundings can affect their health. By staying informed, they can take steps to protect themselves—like keeping medicine safe during power outages, avoiding known triggers, or planning for bad weather. Understanding the environment’s role is an important part of living well with autoimmune disease.

Why Young Adulthood Is a Key Window for Autoimmune Disease

Adolescence and early adulthood are highly dynamic periods for the immune system. Several factors make this age range particularly vulnerable to disease onset:

  • Hormonal changes during puberty, menstrual cycles, pregnancy, or starting/stopping birth control
  • High stress levels related to school, exams, relationships, finances, or early career pressure
  • Sleep disruption, irregular schedules, and late nights
  • Environmental triggers including infections, pollutants, or changes in diet
  • Major life transitions, such as moving out, navigating healthcare independently, or balancing multiple responsibilities

Because many autoimmune symptoms—fatigue, anxiety, headaches, digestive issues—can look like typical “young adult” experiences, it’s common for teens and 20-somethings to go years without clear answers.

Autoimmune Diseases That Commonly Affect Young Adults

Autoimmune diseases can occur at any age, but several conditions frequently begin in adolescence or early adulthood. These include:

Autoimmune Thyroid Diseases (Hashimoto’s & Graves’)

Frequently diagnosed in teens and young adults. Symptoms like fatigue, weight changes, anxiety, or brain fog are often dismissed as “normal stress,” delaying answers. Learn more about Hashimoto’s | Learn more about Graves’

Celiac Disease

Increasingly diagnosed in teens and college-age young adults. Symptoms can include digestive issues, migraines, joint pain, fatigue, or mood changes. Learn more

Crohn’s Disease

Often diagnosed in the late teens and twenties, Crohn’s is a form of inflammatory bowel disease that can cause abdominal pain, diarrhea, weight loss, fatigue, and nutrient deficiencies. Symptoms can be unpredictable and may flare during stressful periods, making school, social life, and daily routines especially challenging for young adults. Learn more

Juvenile Idiopathic Arthritis 

Inflammatory joint symptoms—stiffness, pain, swelling—can start in childhood or the early adult years, sometimes limiting physical activity or mobility. Learn more

Lupus (Systemic Lupus Erythematosus)

Most commonly begins between ages 15–35, disproportionately affecting young women. Symptoms may include fatigue, joint pain, skin rashes, and organ involvement. Learn more

Multiple Sclerosis (MS)

A leading neurological autoimmune disease among young adults. Many people experience their first symptoms—numbness, vision issues, weakness—in their 20s or early 30s. Learn more

Psoriasis & Psoriatic Arthritis

Often begin in late teens or early adulthood, affecting both skin and joints and sometimes impacting self-confidence or daily routines. Learn more about psoriasis | Learn more about psoriatic arthritis

Type 1 Diabetes

Often diagnosed in childhood, the teen years, or the early twenties. Its daily management can impact school, sports, and social activities. Learn more

Explore our comprehensive library of autoimmune diseases here.

Tips for Young Adults Living With Autoimmune Disease

Everyone’s autoimmune journey is different, but these general tips can help you start building a toolkit that fits your life.

Build a Care Team That Listens

  • Keep a symptom journal (fatigue levels, pain, food, stress, sleep, flares).
  • Don’t be afraid to ask, “What are the possible diagnoses you’re considering?”
  • If you feel dismissed, it’s okay to seek a second opinion.
  • Bring a friend, parent, or partner to important appointments for support and note-taking.

Make School or Work More Sustainable

  • Connect with your school’s disability or accessibility office to explore accommodations like flexible attendance, extended time, or remote options during flares.
  • At work, learn about your rights to reasonable accommodations, such as flexible hours, ergonomic setups, or hybrid/remote days.
  • Use “energy budgeting”: treat your energy like money and plan your week so you’re not overspending every day.

Take Care of Your Mental Health

  • Autoimmune disease is linked with higher rates of anxiety and depression—this is not “all in your head,” and you’re not weak for struggling.
  • Consider talking with a therapist or counselor familiar with chronic illness.
  • Try grounding practices that fit your style: guided breathing, short walks, journaling, art, or even gaming or TV as a mental break.

Communicate Your Needs (Without Over-Explaining)

You get to decide who knows what. A simple script can go a long way:

  • To friends: “I live with an autoimmune condition that can cause unpredictable fatigue and pain. I might need to change plans last minute, but it doesn’t mean I don’t want to be there.”
  • To professors or supervisors: “I have a chronic autoimmune disease that sometimes limits my energy and mobility. I’m committed to doing my best and would appreciate some flexibility with deadlines/attendance when symptoms flare.”

Create a Flare Plan

Think ahead about what helps you get through bad days:

  • Keep easy meals and snacks on hand.
  • Prepare a “flare kit”: comfy clothes, medications, heat/cold packs, water bottle, entertainment.
  • Draft template messages you can send when you need to cancel plans or request extensions.
  • Let a trusted friend or family member know what you need when things get rough.

Find Your People

  • Look for online or local groups for young adults with autoimmune disease or your specific condition.
  • Follow patient advocates and reputable medical organizations on social media.
  • Share your story only if and when you’re ready—but know that your voice has power.

Resources for Young Adults

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Know Your Rights: Medical Accommodations for Students

Medical accommodations are adjustments or support provided by your school to help you fully participate in your education—even when health issues get in the way. Whether you have an autoimmune disease, a food allergy, a mental health condition, or another chronic illness, you may qualify for accommodations that make learning more accessible and safe.

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Resources and Strategies for Managing High School and College with Autoimmune Disease

High school and college can be challenging for any student, but for those living with chronic conditions like autoimmune disease, it can come with unique hurdles. From managing specific meal plans and medication schedules to securing accessible parking or requesting special accommodations from teachers, students with chronic illnesses must often balance their health needs with school responsibilities.

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Spot the Red Flags: A Guide to “Miraculous” Health Claims

Learn how to separate legit health info from hype, scams, and too-good-to-be-true claims online.

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Video—What It's Really Like: Young Adults Discuss Autoimmune Disease

This webinar brings together members of the Autoimmune Association’s Young Adult Advisory Council (YAAC) for an honest conversation about navigating autoimmune disease in young adulthood. Panelists discuss what it’s like to be diagnosed at a young age, move from pediatric to adult healthcare, and manage treatment decisions while balancing everyday life. The discussion also highlights the importance of self-advocacy, managing limited energy, and overcoming insurance and access challenges.

Young Adult Advisory Council: Your Voice Matters

The Young Adult Advisory Council (YAAC) of the Autoimmune Association is a group of young adults living with autoimmune disease who:

  • Share their lived experience to shape programs, resources, and advocacy
  • Help us understand what young adults really need from healthcare, policy, and community
  • Participate in panels, webinars, storytelling projects, and awareness campaigns
  • Build connection and peer support with others facing similar challenges

Their insights help ensure that everything we create—especially for young adults—is by patients, for patients, not just “about” patients.

If you’re interested in learning more about the Young Adult Advisory Council, future application cycles, or ways to get involved, please get in touch.

Learn more

 

Young. Strong. Empowered.

Autoimmune disease can make young adulthood complicated, but it doesn’t erase your dreams. With the right information, tools, and community, you can still build a life that feels meaningful, exciting, and yours.